Hints for purchase of computing resources

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Quite often, Dynamo users ask us questions like "which computer do I need to use Dynamo", "should I buy some special equipment?". This page serves as a guide on the points you should consider to decide if and what resources you need to purchase.

As a first point, bear in mind that there are very different tasks that can be performed by Dynamo, and they will run optimally in different machines. On-line navegation of tomograms is a very different operation than parallel nmber crunching of thousand of particles!

Visualization Worsktation

If you are interested in using Dynamo for interacting with your tomograms (visualization, annotation, etc), you should get a reasonably good workstation. A suitable machine should be able to fit tomograms in its memory comfortably. A RAM memory of at least 32 Gb is not so expensive these days, and will save you a lot of frustration in front of your screen.

This is a very reasonable investment. Operating on tomograms in a remotely located machine makes interaction sluggish and frustrating. And a powerful workstation will be useful for many other tasks of Structural Biology


A good workstation will probably provide at least 8 cores without forcing your budget. Although it's not strictly necessary for visualization, there are some additional ancillary operations frequently needed in Dynamo that benefit from parallelization: particle cropping, averaging, some steps in PCA analysis, manual management of models. Even alignment projects with modest number of particles can be reasonably executed on a local workstation. Thus, having in your local machine 24 cores will not be an useless luxury. You'll use them, although probably not as often as other features of your workstation, so of you want to keep your budget low, do not buy too many cores.


We strongly encourage to run Dynamo on two screens when you are visualizing tomograms. Dynamo tends to create lots of graphical windows to offer different functionalities. A Dynamo session can easily overcrowd a single screen...

Dedicated GPU servers for number crunching

For real number crunching we recommend trying to buy your own dedicated server. Our typical setting is a rack mounted unit with CPU with 8 cores and, moving 8 GPU machines.

Requirements on the CPU

For Dynamo you don't need a lot of memory. If you are planning to buy a machine just for Dynamo, a RAM of 16Gb should be enough fro the CPU that harnesses the GPU devices. Bear in mind however that other CryoEM software (as Relion) may require a much more memory. A RAM of 256 of 512Gb is very expensive, so that if you are on a tight budget you should make your planning according to the intended purpose of the machine.

Practical considerations

We suggest directly contacting your IT admins to make certain that the data center in your institution will be able to host the GPUs you want to buy, in terms of space in the racks, appropriate cooling and powering, etc...

File systems

While you don't need any special type of file system, it is comfortable to have

External computing resources


Many research institutions offer access to computing clusters, both for CPU and/or GPU machines. They are normally accessed through a queue that distributes the available resources among many users. This option requires some tedious adaption to the syntax of the queuing system.

Cloud computing

Dynamo will shortly deliver a (free) virtual environment for the Amazon EC2 cloud. In this setting, you don't need to purchase and maintain any hardware, or install any software. Users just pay Amazon for the time they actually use.